Impact of Perioperative Levosimendan on Patients Undergoing Cardiac Surgery With Low Ejection Fraction

Zagazig University

Status and phase: Completed; Phase 2

Conditions: Cardiac Surgery; Low Ejection Fraction

Treatments: Drug: levosemindan; Drug: adrenaline,noreadrenaline,dopamine and doputamine

Study type: Interventional

Funder types: Other

Identifiers

NCT06784570

ZU-IRB # 737/15-oct-2024

Details and patient eligibility

About

to compar levosemindan to other cardiac intropic medications that strengthen the heart in diffrent common adult heart surgery with patients with low ejection fraction(weak heart)

Full description

in this study show the effect of levosemindan use during coronary artery surgery ,heart valve surgery and combined coronary and valve surgery in comparison to other traditional medications with patients with low ejection fraction(weak heart)

Enrollment: 240 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Valve surgery
2. CABG surgery,
3. combined surgery
4. all patients Ejection Fraction less than 35 ٪ -

Exclusion criteria

1. Patients age ≤ 20-70 < years
2. Aortic and redo surgery
3. any patients with Ejection Fraction more than 35 ٪ -

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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240 participants in 2 patient groups

levosemindan

Experimental group

Description:

this group of patients will recieve levosemindan

Treatment:

Drug: levosemindan

traditional

Active Comparator group

Description:

this group of patients will recieve traditional intropic drugs

Treatment:

Drug: adrenaline,noreadrenaline,dopamine and doputamine