Impact of Peripheral Nerve Blockade on Outcomes After Total Knee Replacement

Ottawa Hospital Research Institute

Status: Completed

Conditions: Osteoarthritis; Pain

Treatments: Other: Peripheral nerve block

Study type: Observational

Funder types: Other

Identifiers

NCT02742961

DM1

Details and patient eligibility

About

Pain is common after knee replacement surgery and can impact a variety of patient outcomes. Peripheral nerve blocks provide improved pain control and may improve function. However, their impact on other outcomes is poorly described. Therefore, this comparative effectiveness study will estimate the independent association between nerve blocks and health outcomes after knee replacement surgery.

Full description

This retrospective, population-based cohort study will evaluate the comparative effectiveness of peripheral nerve blocks on patient and health system outcomes after elective total knee replacement surgery.

The investigators will develop a non-parsimonious propensity score to control for potential indication bias and confounding in this observational study. Using the propensity score the investigators will match patients who receive a peripheral nerve block to a patient who did not to estimate the independent association of peripheral nerve blocks with our study outcomes.

Enrollment: 178,214 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• first primary total knee replacement during the study period

Exclusion criteria

• Revision arthroplasty

Trial design

178,214 participants in 2 patient groups

Peripheral nerve block

Description:

Intervention arm. Participants who receive a peripheral nerve block identified through submission of an appropriate physician billing code

Treatment:

Other: Peripheral nerve block

No peripheral nerve block

Description:

Control arm. Participants who do not receive a peripheral nerve block identified through lack of a submission of an appropriate physician billing code