Impact of Personality on Adherence to Tyrosine Kinase Inhibitor Therapy in Pts w/Chronic Myeloid Leukemia

University of California Irvine (UCI) logo

University of California Irvine (UCI)

Status

Not yet enrolling

Conditions

Chronic Myeloid Leukemia
Chronic Phase Chronic Myelogenous Leukemia

Treatments

Other: Interview

Study type

Observational

Funder types

Other

Identifiers

NCT06229860
3709
UCI 23-110 (Other Identifier)

Details and patient eligibility

About

This is an observational pilot study to examine the association between a patient's personality and adherence to tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia.

Full description

The purpose of this pilot study is to explore the association between personality and adherence to a specific type of oral cancer medication - tyrosine kinase inhibitor (TKI) - in patients with chronic myeloid leukemia (CML). 75 individuals with chronic phase CML who are being treated with TKIs will be recruited. Consenting patients will participate in a focused interview where TKI adherence, personality type, and quality of life and symptom burden will be assessed using validated questionnaires. Information on treatment response and the treating physician's perception of TKI adherence will be obtained from the electronic health record.

Enrollment

75 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • 18 years of age or older
  • Diagnosed with chronic myeloid leukemia (CML) and in the chronic phase (CML-CP)
  • Currently being treated with one of four cancer medications - imatinib, dasatinib, bosutinib, or nilotinib
  • A patient at the UCI Chao Family Comprehensive Cancer Center (CFCCC), or
  • A member of a patient support group organized by the CML Buster Foundation
  • Do not meet any of the criteria listed under "Exclusion Requirements"

Exclusion criteria

  • Unable to read and speak English
  • Impaired decisional capacity to consent

Trial design

75 participants in 1 patient group

Adult patients with CML in chronic phase (CML-CP)
Treatment:
Other: Interview

Trial contacts and locations

1

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Central trial contact

Chao Family Comprehensive Cancer Center University of California, Irvine; University of California Irvine Medical

Data sourced from clinicaltrials.gov

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