Impact of Platinum-based Cancer Treatment on Endothelial Function

I.M. Sechenov First Moscow State Medical University

Status: Completed

Conditions: High Blood Pressure; Cardiovascular Complication

Study type: Observational

Funder types: Other

Identifiers

NCT04681560

1019

Details and patient eligibility

About

In this research we investigate endothelial function in cancer patients who received platinum based chemotherapy.

Full description

The goal of the study is to evaluate endothelial function in patients with platinum-based versus non-platinum-based chemotherapy.

Endothelial function was evaluated via Angioscan( the apparatus that evaluate the stiffness of vessels by pulse wave velocity) and serum levels of endothelial nitric oxide synthase (ENOS),endothelin1.

Patients with gastrointestinal, ovarian, bladder and brest cancer would be included.

Patients with malignancies were followed-up from 2 weeks to 3 month after start of chemotherapy, Medical records and hospital databases were searched for all the patients treated with different chemotherapy treatment for any kind of cancer.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subject has solid cancer
• Subject is expected to start chemotherapy

Exclusion criteria

• Pregnancy and lactation
• Severe impaired kidney function
• Severe hepatic impairment
• Mental disease
• Acute myocardial infarction 28 days ago or earlier
• Acute Cerebrovascular Event 1 month ago or earlier
• Rhythm disturbance that complicate pulse wave velocity evaluation