Impact of Pollution on Allergic Rhinitis and Sleep Quality: the POLLAR Study

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Allergic Rhinitis; Sleep Apnea; Pollution Exposure; Allergic Asthma; Pollution Related Respiratory Disorder

Treatments: Other: Pollution exposure

Study type: Interventional

Funder types: Other

Identifiers

NCT03776773

38RC18.264

Details and patient eligibility

About

It has been demonstrated that allergic rhinitis (AR) reduces sleep quality by some components such as nasal obstruction. Pollution and allergen exposure worsening AR, sleep quality is deteriorated.

Sleep is associated to physical and mental health, alterations in sleep could explain the link between AR and work productivity diminution, impairment in daily activities or emotional problems.

However, interactions between air pollution, sleep and allergic diseases are insufficiently understood.

The main objective of this study is to determine the impact of pollution and pollens on sleep parameters.

Full description

Over 150 million people have allergic rhinitis (AR) in Europe and around 30% have uncontrolled AR during allergen exposure. It has been demonstrated that AR reduces sleep quality by some components such as nasal obstruction. Pollution and allergen exposure worsening AR, sleep quality is deteriorated.

Sleep is associated to physical and mental health, alterations in sleep could explain the link between AR and work productivity diminution, impairment in daily activities or emotional problems.

However, interactions between air pollution, sleep and allergic diseases are insufficiently understood.

Moreover, the prevalence of OSA in patients with AR is higher than in subjects without AR. Nasal obstruction could explain the increased risk of OSA.

This prospective, open study will compare sleep quality in 2 different groups: AR patients and patients without AR during the pollen season and outside the pollen season.The main objective is to determine the impact of pollution and pollens on sleep parameters for subjects with AR

Enrollment: 52 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-65 years
• Be able to use an application on a personal smartphone
• Patient non treated for OSA
• Be legally able to give consent
• Person affiliated to social security

Exclusion criteria

• Being unable to understand, follow objectives and methods due to cognition or language problems Subjects listed in articles L1121-5 à L1121-8: Pregnant women, feeding and parturient; subject under administrative or judicial control, persons who are protected under the act.

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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52 participants in 4 patient groups

patients AR (+) and sleep apnea (+)

Active Comparator group

Description:

Patients with AR and obstructive sleep apnea (OSA) will have sleep and pollution exposure recordings

Treatment:

Other: Pollution exposure

AR (-) and sleep apnea (+)

Active Comparator group

Description:

Patients without allergic rhinitis (+ sleep apnea) will have sleep and pollution exposure recordings

Treatment:

Other: Pollution exposure

AR (+) and sleep apnea (-)

Active Comparator group

Description:

Patients with allergic rhinitis but no sleep apnea will have sleep and pollution exposure recordings

Treatment:

Other: Pollution exposure

AR (-) and sleep apnea (-)

Sham Comparator group

Description:

Volunteers without allergic rhinitis and no sleep apnea will have sleep and pollution exposure recordings

Treatment:

Other: Pollution exposure