Impact of Polymorphism on Pulmonary Pressure in Subjects With Pulmonary Hypertension of Different Cause

University of Leipzig

Status: Completed

Conditions: Pulmonary Hypertension; Congestive Heart Failure

Study type: Observational

Funder types: Other

Identifiers

NCT00893178

SMW 03

Details and patient eligibility

About

Pulmonary Hypertension (PH) is a disease that is characterized by vasoconstriction of small vessels of the lung. Many cases do have proliferation of endothelial cells within these vessels. A possible influence of polymorphisms of genes relevant for inflammatory and endothelial processes is suspected.

Especially patients with chronic heart failure can develope PH. The reasons therefore are lacking.

The researchers investigate different polymorphism and the influence of these on pulmonary artery pressure (measured invasively) in patients with congestive heart failure (CHF) and patients with primary pulmonary hypertension.

Full description

The study consists of 3 arms-patients with CHF and PH, patients with CHF without PH and patients without CHF and PH.

The PH measurement is due to routine catheterization, thereafter we measure different vasoactive polymorphism.

Enrollment: 350 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CHF with or without pulmonary hypertension or
• patients with normal LVEF and pulmonary hypertension
• right heart catheterization due to routine
• informed consent

Exclusion criteria

• no right heart catheterization
• no informed consent
• elevated pulmonary pressure due to valve diseases or congenital heart disease

Trial design

350 participants in 3 patient groups

CHF with elevated PAP

Description:

CHF patients (LVEF \> 35%) with elevated mean pulmonary pressure( \> 20 mmHg ) measured by pa catheter

CHF patient without elevated PAP

Description:

CHF patients (LVEF \> 35%) with normal mean pulmonary pressure

Normal EF with elevated PAP

Description:

Patients with normal LVEF \< 60% with elevated mean pulmonary pressure