Impact of Prebiotics in Ulcerative Colitis

University of California, Los Angeles (UCLA)

Status

Enrolling

Conditions

Ulcerative Colitis

Crohn Disease

Treatments

Dietary Supplement: Prebiotic

Study type

Interventional

Funder types

Other

Identifiers

NCT06495658

24-000256

Details and patient eligibility

About

The cause of inflammatory bowel disease (IBD) is currently unknown, although partly attributed to interactions among genetic risk polymorphisms, environmental factors, gut microbiome, and host immunity. Diet, particularly those with plant-based products, have been shown in prior research to improve gut microbial composition, which has been linked to different IBD-related outcomes. This study is interested in evaluating the impact of prebiotics on gut microbiome composition and gut health in patients with IBD.

Dietary composition will be assessed at baseline and over the course of 16 weeks. Participants will be randomized to either consume an 8-week course of prebiotic supplementation beginning at week 0 or week 8. Stool samples will be collected at weeks 0 and 8. The stool will be analyzed for cross-sectional and longitudinal fecal microbial changes associated with different prebiotic and diet consumption patterns in the context of heterogeneous disease characteristics.

Enrollment

70 estimated patients

Sex

All

Ages

18 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Ages 18 to 85 years old
History of biopsy-proven ulcerative colitis (UC)
Active symptoms (SCCAI >2)
Concomitant use of 5-aminosalicylates, immunomodulators, and corticosteroids will be permitted, although initiation or dose adjustment must not have occurred within 30 days prior to enrollment.
Concomitant use of biologic therapy will be permitted, although initiation or dose adjustment must not have occurred within 60 days prior to enrollment.
Prior probiotics or other dietary supplements use is permitted but will be asked to be discontinued during the course of the trial

Exclusion criteria