Impact of Prior SGLT2 Inhibitors Use on the Development and Progression of Sepsis-Associated Acute Kidney Injury

University of Jazan

Status: Completed

Conditions: Acute Kidney Injury; Septic Shock; Sepsis

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT06902493

SGLT2I-AKI

Details and patient eligibility

About

The primary objective of this study is to investigate whether using SGLT2i may be associated with decreased incidence of sepsis-induced AKI or not.

Full description

The primary objective of this study is to investigate whether using SGLT2i may be associated with decreased incidence of sepsis-induced AKI or not.

Enrollment: 664 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All adult (≥ 18 year) patients who were admitted to ICU with sepsis syndromes (sepsis or septic shock), according to sepsis-3 definition.

Exclusion criteria

• Missing data
• Renal transplant or tumor
• Solitary kidney
• Established CKD
• Obstructive uropathy
• Renal artery stenosis
• Pregnancy

Trial design

664 participants in 2 patient groups

SA-AKI Group

Description:

Patients diagnosed with sepsis syndromes (sepsis or septic shock) and AKI according to sepsis-3 definition and KDIGO criteria, respectively

Treatment:

Other: No intervention

No AKI group

Description:

Patients diagnosed with sepsis syndromes (sepsis or septic shock) and AKI according to sepsis-3 definition

Treatment:

Other: No intervention