Impact of Probiotic Regimen on Vancomycin Resistant Enterococcus Intestinal Carriage

University Hospital, Clermont-Ferrand

Status and phase: Unknown; Phase 4

Conditions: Vancomycin Resistant Enterococcus Intestinal Carriage

Treatments: Drug: Lactobacillus casei rhamnosus (strain Lcr 35 LC)

Study type: Interventional

Funder types: Other

Identifiers

NCT00437580

CHU63-0015

Details and patient eligibility

About

This study aims to reduce the duration of VRE intestinal carriage by the administration of Lactobacillus casei rhamnosus (strain Lcr 35 LC). Patients will be blindly randomized to be assigned to a 5 weeks regimen with the probiotic (10 9 lactobacillus bid) or to a 5 weeks regimen with placebo.A stool culture will be performed every week for 5 weeks (during the administration of treatment) then every two weeks until 3 consecutive negative stool culture for VRE.

Full description

This study aims to reduce the duration of VRE intestinal carriage by the administration of Lactobacillus casei rhamnosus (strain Lcr 35 LC). Patients will be blindly randomized to be assigned to a 5 weeks regimen with the probiotic (10 9 lactobacillus bid) or to a 5 weeks regimen with placebo.A stool culture will be performed every week for 5 weeks (during the administration of treatment) then every two weeks until 3 consecutive negative stool culture for VRE.

Enrollment: 24 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >18;
• Vancomycin Resistant Enterococcus intestinal carriage

Exclusion criteria

• Neutropenia <1000 /mm3,
• Immunosuppressive drugs,
• Inhalation