Impact of Prokinetic Use After Emergency Intestinal Anastomosis on Postoperative Clinical Outcomes

Sohag University

Status: Unknown

Conditions: Prokinetic Use After Emergency Intestinal Anastomosis

Treatments: Drug: Prokinetic Motility Agents as primpiram and gastreg

Study type: Interventional

Funder types: Other

Identifiers

NCT05290753

Soh-Med-22-02-09

Details and patient eligibility

About

Prokinetic drugs used to accelerate healing of intestinal anastomosis of urgent cases which not prepared preoperative by increase intestinal motility and gastric emptying and decrease postoperative adhesions They are many types of prokinetics as cholinergic agonists, dopamine antagonist, serotonergic agonists and macrolides Agents of prokinetics administered immediately post operation and at the time of hospitalization

Full description

By evaluation the effect of prokinetic use versus non use after emergency intestinal intestinal anastomosis on short and long term clinical outcome It will be prospective cohort study which conducted in sohag university hospital Study will include patients presented with urgent anastomosis Inclusion criteria: all adults underwent emergency intestinal anastomosis Exclusion criteria: pediatrics, patients with comorbidities and patients with electively resection and anastomosis.

Primary goals are to detect effect of prokinetics on incidence of leakage rate Secondary outcomes include early bowel opening, enteral feeding, post operative pain, wound infection and adhesion formation rate.

Enrollment: 15 estimated patients

Sex: All

Ages: 12+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• all adult patients

Exclusion criteria

• pediatrics
• patients associated with comorbidities
• patients with electively resection and anastomosis

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

Prokinetic use in accelerate healing of urgent intestinal anastomosis

Other group

Description:

Prikinetic agents administered immediately post operative and time of stay at hospital twice daily

Treatment:

Drug: Prokinetic Motility Agents as primpiram and gastreg