Impact of Protamine Dose Reduction on Platelet Aggregation After Extracorporeal Circulation for Minimally Invasive Aortic Valve Replacement Surgery

U

University of Liege

Status

Not yet enrolling

Conditions

Protamine Dose
Protamine Adverse Reaction

Treatments

Drug: Low dose protamine

Study type

Interventional

Funder types

Other

Identifiers

NCT06254404
LowProt

Details and patient eligibility

About

Determining the minimum effective dose of protamine after extracorporeal circulation for mini-sternotomy aortic valve replacement surgery.

Enrollment

50 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Mini-sternotomy aortic valve replacement surgery
  • Major patients

Exclusion criteria

  • Hypersensitivity to protamine
  • Coagulation Abnormalities
  • Heparin allergy
  • Pregnant women
  • Jehovah's Witnesses

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

50 participants in 2 patient groups

Low dose of Protamine
Active Comparator group
Treatment:
Drug: Low dose protamine
Normal dose of protamine
Experimental group
Treatment:
Drug: Low dose protamine

Trial contacts and locations

0

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Central trial contact

Benjamin Javillier, MD

Data sourced from clinicaltrials.gov

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