Impact of Protamine Dose Reduction on Platelet Aggregation After Extracorporeal Circulation for Minimally Invasive Aortic Valve Replacement Surgery

University of Liege

Status: Not yet enrolling

Conditions: Protamine Dose; Protamine Adverse Reaction

Treatments: Drug: Low dose protamine

Study type: Interventional

Funder types: Other

Identifiers

NCT06254404

LowProt

Details and patient eligibility

About

Determining the minimum effective dose of protamine after extracorporeal circulation for mini-sternotomy aortic valve replacement surgery.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mini-sternotomy aortic valve replacement surgery
• Major patients

Exclusion criteria

• Hypersensitivity to protamine
• Coagulation Abnormalities
• Heparin allergy
• Pregnant women
• Jehovah's Witnesses

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

Low dose of Protamine

Active Comparator group

Treatment:

Drug: Low dose protamine

Normal dose of protamine

Experimental group

Treatment:

Drug: Low dose protamine