Impact of Reduction of Dust Mite Allergenic Load on Step Down of Inhaled Corticosteroids in Stable Asthma

Centre Hospitalier Universitaire Saint Pierre

Status: Terminated

Conditions: Asthma

Treatments: Device: Acar'up system; Device: Acar'up placebo system

Study type: Interventional

Funder types: Other

Identifiers

NCT02773628

AK/15-12-127/4581

Details and patient eligibility

About

Eviction methods for dust mite allergy have been evaluated in asthma control in a recent Cochrane meta-analysis. None have shown efficacy on asthma control and there are not recommended. The purpose is to evaluate the efficacy of a new commercialized system (Acar'Up) to decrease dust mite load and to assess its impact on the possibility to perform inhaled corticosteroids step down in stable asthmatics.

Full description

Eviction methods for dust mite allergy have been evaluated in asthma control in a recent Cochrane meta-analysis. None have shown efficacy on asthma control and there are not recommended. The purpose is to evaluate the efficacy of a new commercialized system, Acar'Up (a spray pulverized on a technical textile that traps the dust mite) to decrease dust mite load and to assess its impact on the possibility to perform inhaled corticosteroids step down in stable asthmatics.

Enrollment: 3 patients

Sex: All

Ages: 16 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• confirmed asthma diagnosis
• controlled asthma for more than 3 months
• treatment with inhaled corticosteroids
• dust mite allergy proved by skin tests ou specific immunoglobulin E

Exclusion criteria

• chronic obstructive pulmonary disease, bronchiectasis, Fibrosis, tuberculosis
• asthma-chronic obstructive pulmonary disease overlap syndrome
• ongoing desensitization for dust mite
• pregnancy
• previous use of Acar'up

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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3 participants in 2 patient groups, including a placebo group

control group

Placebo Comparator group

Description:

stable asthmatics receiving an Acar'up placebo system

Treatment:

Device: Acar'up placebo system

treatment group

Active Comparator group

Description:

stable asthmatics receiving Acar'up system

Treatment:

Device: Acar'up system