Impact of Regular Consumption of Grapes on Eye Health in Singapore Older Adults

National University of Singapore

Status

Active, not recruiting

Conditions

Age-related Macular Degeneration

Eye Health

Treatments

Dietary Supplement: Freeze-dried table grape powder

Dietary Supplement: Placebo of the table grape powder

Study type

Interventional

Funder types

Other

Identifiers

NCT05064865

S15

Details and patient eligibility

About

Aging epidemics in Singapore are rapidly increasing and Age-related macular degeneration (AMD) prevalence is significantly associated with older age. This study aims to understand the effect of consuming freeze-dried table grape powder on AMD in an older population.

Full description

This will be carried out through a 16-week double-blind, randomized, placebo-controlled trial of parallel study design. Thirty-eight men and women (aged between 60 and 85 years old inclusive) will recruited and assigned to an intervention or placebo group. The intervention group will consume 46 g/day of a freeze-dried table grape and the control group will consume the same amount of a placebo, table grape placebo powder. Measurements of 1) macular pigment optical density (MPOD), a clinical marker for eye health, 2) carotenoids status, 3) markers of oxidative stress, 4) markers of endothelial function, 5) body size and blood pressure, and 6) dietary assessment will be assessed over the 16-week study. This study will consist of 1 screening visit and 5 study visits in 4-week intervals to the Food Science and Technology Department, Occupational Health Clinic and National University Heart Centre.

Enrollment

34 patients

Sex

All

Ages

60 to 85 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Male and female participants, aged between 60 and 85 years old inclusive
Able to give informed consent in English

Exclusion criteria

Smokers
Allergy to grapes
Known eye diseases (macular degeneration, cataracts, retinopathy or glaucoma), blindness in at least one eye or have had eye surgery
Abnormal kidney and liver function
Taking eye medication and/or dietary supplements for the eyes for the past 3 months
Taking supplements containing carotenoids (e.g. Vitamin A, lutein, zeaxanthin) for the past 3 months
Currently on type 2 diabetic medication.
Currently on anti-hypertensive or cholesterol-lowering; unless this prescription has been ongoing for more than 3 years prior to study participation.
Currently on a specialized diet (e.g. vegetarian, vegan, weight loss diet, low fat diet)
Consumes more than 2 alcoholic drinks per day i.e. one drink is defined as either 150ml of wine, 340ml of beer/cider or 45ml of distilled spirit.
Significant change in weight (≥ 3 kg body weight) in the past 3 months
Significant exercise pattern over the past 3 months defined as high-intensity exercise of more than 3 hours per week
Poor peripheral venous access based on past experiences with blood draw
Participating in another clinical study