Impact of Relationship of Epilepsy and Attention Deficit Hyperactive Disorder

Assiut University

Status: Completed

Conditions: Attention-Deficit Hyperactivity Disorder; Epilepsy

Treatments: Other: psychometric scales for assesment socioeconomic and behaviour problems; Diagnostic Test: psychometric scales to diagnosis psychiatric disorders; Diagnostic Test: electroencephalography

Study type: Observational

Funder types: Other

Identifiers

NCT03806946

Impact of ADHD and epilepsy

Details and patient eligibility

About

The most common neuropsychiatric disorder in early childhood is attention deficit/hyperactivity disorder (ADHD) with evidence of abnormality in structure and function of brain. Epilepsy is one of the commonest comorbidity associated with ADHD with negative outcome on childrens' quality of life, and is considered to be a risk for academic underachievement. These two disorders are highly associated, with more possibility to be a bidirectional relationship. The mechanisms of this comorbidity are unknown. In this association, a difficult challenge is presented since antiepileptic therapy and drugs used to treat ADHD may aggravate the clinical picture of each other. The main objectives are to evaluate this overlap of those disorders, find their complications on child and his family, and to suggest possible solutions to improve the outcome of those children.

Full description

The commonest childhood disorder is attention deficit hyperactivity disorder(ADHD) which continues into adulthood.The main two symptoms are inattention and hyperactivity.

As epilepsy is one of the commonest comorbidity with ADHD to about (40%), there are many overlap symptoms between both disorders for example:

• Behavioral features which are shared in both frontal lobe epilepsy with ADHD such as impulsivity, disinhibition, and irritability
• The electroencephalogram: there is an increase in the rate of spikes in children with ADHD with no epileptic symptoms, which supports the theory of presence similar mechanism about central nervous system dysfunction.

These reasons lead to increase obstacles for diagnosis, assessment, and treatment for both disorders.

As this comorbidity duplicates the complications (i.e. drop the school, financial cost, stress on families, negative effect on academic, vocational, social relations and self-esteem ) so there is a great need to study this comorbidity to give a proper care for these patients.

In this study, all participants will be enrolled over a period of 12 months from Assiut outpatients clinic .All participants will be assessed in the psychiatric interview by using prepared child and adolescent psychiatric sheet include (psychiatric and neurology history, physical examination and mental state examination). After that electroencephalogram(EEG) will be done to diagnoses epilepsy and identify different types of seizures.

All participants will be categorizing into 4 groups ( ADHD, epilepsy, ADHD,and epilepsy, healthy) according to EEG and the psychiatric sheet. Each group will be assessed by different psychometrics scales to evaluate cognitive, social, economic and behavioral outcome. The results of all groups will be analysed by using Stata version 15 to evaluate the effect of ADHD and epilepsy in children and adolescent and identify the possible risk factors to improve outcome

Enrollment: 100 patients

Sex: All

Ages: 6 to 11 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Both males and females were included.
• Age range from 6- 11 years.
• Diagnosis of ADHD and/or epilepsy was verified and confirmed either on a clinical basis or by using reliable psychometric tests.
• In epilepsy groups: only Idiopathic type was included.
• Willing of the parents or the caregivers to participate in the study.

Exclusion criteria

• Children whom caretakers refused to give informed consent.
• Children with intelligence quotient below 70.
• Children with history or current substance use.
• Children with medical or other neurological conditions.

Trial design

100 participants in 5 patient groups

group1

Description:

ADHD with normal EEG

Treatment:

Diagnostic Test: electroencephalography

Other: psychometric scales for assesment socioeconomic and behaviour problems

Diagnostic Test: psychometric scales to diagnosis psychiatric disorders

group 2

Description:

ADHD with abnormal EEG

Treatment:

Diagnostic Test: electroencephalography

Other: psychometric scales for assesment socioeconomic and behaviour problems

Diagnostic Test: psychometric scales to diagnosis psychiatric disorders

group 3

Description:

Epilepsy

Treatment:

Diagnostic Test: electroencephalography

Other: psychometric scales for assesment socioeconomic and behaviour problems

Diagnostic Test: psychometric scales to diagnosis psychiatric disorders

group 4

Description:

Healthy control group

Treatment:

Diagnostic Test: electroencephalography

Other: psychometric scales for assesment socioeconomic and behaviour problems

Diagnostic Test: psychometric scales to diagnosis psychiatric disorders

group 5

Description:

ADHD and epilepsy

Treatment:

Diagnostic Test: electroencephalography

Other: psychometric scales for assesment socioeconomic and behaviour problems

Diagnostic Test: psychometric scales to diagnosis psychiatric disorders