Impact of Resistance Training Volume on Cognitive Function and Physical Performance in Cognitively Impaired Individuals (TRAIN4BRAIN)

University of Beira Interior

Status: Active, not recruiting

Conditions: Cognitive Impairment

Treatments: Other: One group that performed 15% more volume and increased to 30% (10 Weeks); Other: Control Phase ( 6Weeks); Other: One group that performed 30% more volume and increased to 45% (10 Weeks).; Other: 30% increase in resistance training volume (10 Weeks); Other: 15% increase in resistance training volume (10 Weeks); Other: Control group ( 29 Weeks)

Study type: Interventional

Funder types: Other

Identifiers

NCT06528951

Universidade da Beira Interior

Details and patient eligibility

About

This research project aims to analyze the effects of different resistance training volumes on cognitive function, oxidative stress, inflammatory markers, lipid profile, glycemic status, muscle damage, hemodynamic response, and physical performance in cognitively impaired participants. First, the participants will perform six weeks of resistance training using the same volume for all participants (control phase). The total training volume (sets x repetitions) will be 232 repetitions in the leg press and 160 repetitions in the chest press, with relative intensities ranging from 40% to 70% of 1RM. In week 7, the participants will perform the pre-test, and the outcome measures will be cognitive function, oxidative stress, inflammatory markers, lipid profile, glycemic status, muscle damage, hemodynamic response, and physical performance. After the pre-test, the participants will be randomly assigned into two training groups to perform a 10-week intervention. One group will increase the training volume by 15% concerning the training program performed in the control phase, while the other group will increase the volume by 30%. Participants will perform a control test one week after the intervention to assess hemodynamic parameters and physical performance. One week after the control test, the participants will perform another 10-week resistance training program, where the group that performed a volume of 15% will perform 30%, and the group that performed 30% will perform 45%. One week after the intervention, the participants will perform the post-test, and the outcome measures will be cognitive function, oxidative stress, inflammatory markers, lipid profile, glycemic status, muscle damage, hemodynamic response, and physical performance. The investigators hypothesize that both training volumes will induce similar adaptations in cognitive function, oxidative stress, immune response, lipid profile, glycemic status, muscle damage, hemodynamics, and physical performance in cognitively impaired individuals.

Full description

Following specific inclusion and exclusion criteria (see Eligibility Criteria), participants will be recruited from residential care facilities or day centers. They will perform two different resistance training volumes with two weekly sessions. The intensity of the exercises, the type and order, movement velocity, and rest time between exercises will be the same in both groups. First, a six-week control phase will be carried out, during which all participants will perform the same resistance training volume (control phase). The total training volume (sets x repetitions) will be 232 repetitions in the leg press and 160 repetitions in the chest press, with relative intensities ranging from 40% to 70% of 1RM. After the control phase, a pre-test will be carried out to evaluate cognitive function, oxidative stress, inflammatory markers, lipid profile, glycemic status, muscle damage, blood pressure, heart rate, Short Physical Performance Battery (SPPB: balance, 4-meter walking, and five-repetition sit-to-stand), medicine ball throw (1Kg), handgrip strength, 1RM leg press, and 1RM chest press. After the pre-test, the participants will be randomly assigned into two groups to perform a 10-week resistance training program with different training volumes: one group will increase the training volume by 15% concerning the training program performed in the control phase, while the other group will increase the volume by 30%. After the 10-week intervention, a control test will be performed to evaluate blood pressure, heart rate, SPPB, medicine ball throw (1 kg), handgrip strength, 1RM leg press, and 1RM chest press. After the control test, the participants will perform another 10-week resistance training program where the group that performed the 15% volume will increase to 30% and the 30% volume to 45%. After the second 10-week intervention program, participants will perform the post-test, and the outcome measures will be cognitive function, oxidative stress, inflammatory markers, lipid profile, glycemic status, muscle damage, blood pressure, heart rate, SPPB, medicine ball throw (1 kg), handgrip strength, 1RM leg press, and 1RM chest press. A control group (without any form of physical exercise), recruited at the beginning of the research project, will also be part of the study. The control group will also undergo a battery of tests before and after the intervention. The outcome measures in the control group will be cognitive function, oxidative stress, inflammatory markers, lipid profile, glycemic status, muscle damage, and SPPB (balance, 4-meter walking, and five-repetition sit-to-stand).

Enrollment: 69 patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men or women aged ≥ 50 years old, diagnosed with cognitive impairment (mild, moderate, or severe) through the Dementia Rating Scale-2.
• SPPB score ≥ 3.
• Willingness to participate in training programs and collaborate with the research team.
• Able to provide informed consent (oral or written).

Exclusion criteria

• Severe comorbidity that negatively influences participation in the training program.
• Surgeries or fractures in the last 6 months.
• Bedridden or hospitalized individuals.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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69 participants in 6 patient groups

Control Phase (6 Weeks)

Experimental group

Description:

All recruited participants will perform 6 weeks of resistance training with the same volume. The total training volume (sets x repetitions) will be 232 repetitions in the leg press and 160 repetitions in the chest press, with relative intensities ranging from 40% to 70% of 1RM.

Treatment:

Other: Control Phase ( 6Weeks)

15% increase in resistance training volume (10 Weeks)

Experimental group

Description:

The participants will perform 10 weeks of resistance training, increasing their initial volume by 15%.

Treatment:

Other: 15% increase in resistance training volume (10 Weeks)

30% increase in resistance training volume (10 Weeks)

Experimental group

Description:

The participants will perform 10 weeks of resistance training, increasing their initial volume by 30%.

Treatment:

Other: 30% increase in resistance training volume (10 Weeks)

15% + 15% increase in resistance training volume (10 Weeks)

Experimental group

Description:

The participants will perform 10 weeks of resistance training. The group that performed the 15% volume will increase to 30%.

Treatment:

Other: One group that performed 15% more volume and increased to 30% (10 Weeks)

30% + 15% increase in resistance training volume (10 Weeks)

Experimental group

Description:

The participants will perform 10 weeks of resistance training. The group that performed the 30% volume will increase to 15%.

Treatment:

Other: One group that performed 30% more volume and increased to 45% (10 Weeks).

Control group ( 29 Weeks)

Experimental group

Description:

The participants will not perform any form of physical exercise during the intervention period of twenty-nine weeks.

Treatment:

Other: Control group ( 29 Weeks)