Impact of Resveratrol on Brain Function and Structure

Max Planck Institute for Human Cognitive and Brain Sciences

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Placebo; Dietary Supplement: resveratrol supplementation

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02621554

resveratrol_mpi_01

Details and patient eligibility

About

The study will investigate whether resveratrol could provide positive effects on memory and brain structures and functions in healthy elderly participants.

Full description

Cell and animal studies postulated various beneficial effects of resveratrol, ranging from a reduction of inflammatory processes and the treatment of cancer to the prevention of cardiovascular diseases and stroke. With regard to cognitive decline, rodent models for Alzheimer's disease (AD) showed improved learning and decelerated hippocampal neurodegeneration after intake of resveratrol.

Animal and first human studies provided evidence that resveratrol might serve as an easy, cost-effective option to develop novel prevention and treatment strategies against age-associated cognitive decline. To test this hypothesis, the researchers study general brain structure and function on healthy older individuals (> 60years old).

Enrollment: 60 patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• subjects who are healthy or with subjective memory complaints
• older than 60 years old
• normal to overweight participants (BMI: 22-40 kg/sqm)

Exclusion criteria

• dementia
• Psychiatric diseases
• severe untreated internal diseases
• diabetes
• younger than 60 years
• BMI < 22 or >40

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups, including a placebo group

resveratrol supplementation

Experimental group

Description:

Dietary Supplement: Resveratrol

Treatment:

Dietary Supplement: resveratrol supplementation

placebo supplementation

Placebo Comparator group

Description:

Dietary Supplement: Placebo

Treatment:

Dietary Supplement: Placebo