Impact of Rutin and Vitamin C Combination on Oxidative Stress, Insulin Sensitivity and Lipid Profile in Type 2 Diabetic Patients

Ain Shams University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Type 2 Diabetes Mellitus

Treatments: Dietary Supplement: Rutin in combination with Vitamin C; Dietary Supplement: Vitamin C

Study type: Interventional

Funder types: Other

Identifiers

NCT03437902

PHCL39

Details and patient eligibility

About

The objective of this study is to investigate the effect ofRutin and Vitamin C combination in comparison with vitamin C alone on the oxidative and antioxidative status , insulin resistance and lipid profile in type 2 diabetic patients.

Enrollment: 53 patients

Sex: All

Ages: 35+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Patients' age 35 years or older having type 2 diabetes mellitus.

  • Patients taking oral diabetic medications (Sulfonylurea) not taking Insulin.
  • Able to understand and willing to sign a written informed consent document

Exclusion criteria

• • Pregnant and breast feeding females

  • use of vitamin supplements containing vitamin C or other antioxidants.

• patients with renal or hepatic failure.

• patients taking insulin as antidiabetic treatment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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53 participants in 3 patient groups

Rutin C group

Experimental group

Description:

patients will receive Rutin 60 mg in combination with vitamin C 160 mg three times daily in addition to usual antidiabetic treatment for 8 weeks..

Treatment:

Dietary Supplement: Rutin in combination with Vitamin C

Vitamin C group

Experimental group

Description:

patients will receive vitamin C 500 mg once daily in addition to usual antidiabetic treatment for 8 weeks.

Treatment:

Dietary Supplement: Vitamin C

Control group

No Intervention group

Description:

patients will receive their usual antidiabetic treatment only for 8 weeks.