Impact of Sarcopenia on Dyspnea in Patients with Asthma (MUDYSA)

University Hospital, Clermont-Ferrand

Status: Not yet enrolling

Conditions: Dyspnea; Asthmatic; Myokine; Asthma; Dyspnea; Muscle Disorder; Cytokines; Sarcopenia; Adipokines

Treatments: Combination Product: Questionnaire and Physical Exam; Biological: Dosage; Diagnostic Test: muscle evaluation; Diagnostic Test: Cardiopulmonary exercise test

Study type: Interventional

Funder types: Other

Identifiers

NCT06870890

AOI 2023 ROLLAND-DEBORD

Details and patient eligibility

About

Dyspnea in asthma, is mainly due to airway obstruction but can be caused by several alternative diagnoses.

The impact of sarcopenia on dyspnea in patients with asthma is unknown. Sarcopenic asthma had a reduced physical activity and is associated with airway obstruction compared to non-sarcopenic asthma. In patients with obstructive pulmonary disease, sarcopenia is associated with shallow breathing and diverse sensory and affective components of exertional dyspnea .

The morbidity of sarcopenia is also increased by systemic inflammation and the production of inflammatory cytokines as found in inflammatory airway obstruction.

The investigators will investigate the prevalence and impact of sarcopenia in asthmatics patients. This will enable to better manage sarcopenia in asthmatic patients, understand its origins and personalize treatment.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Patient affiliated to a social security scheme.
• Patient capable of giving free, informed, written and signed consent.
• Asthmatic patients with a diagnosis made by a pulmonologist on GINA level 4 or 5 treatment
• ACT asthma control score < 20
• Patient judged by the investigator to be able to to perform a maximal exercise test.

Exclusion criteria

• Patient under guardianship/trusteeship/supervision of justice
• Pregnant or breast-feeding women
• Unstable heart disease
• Patients who have been smoking or have stopped smoking for less than 5 years,

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

All the patient included in the study

Experimental group

Treatment:

Diagnostic Test: Cardiopulmonary exercise test

Biological: Dosage

Diagnostic Test: muscle evaluation

Combination Product: Questionnaire and Physical Exam