Impact of Serum Progesterone Levels on the Day of Fresh and Frozen Embryo Transfer on the Ongoing Pregnancy Rates.

Hospital Saint Joseph

Status: Completed

Conditions: Infertility

Treatments: Other: serum progesterone measurement

Study type: Observational

Funder types: Other

Identifiers

NCT04839627

PROGESTE

Details and patient eligibility

About

Serum progesterone levels prepare the endometrium for implantation and play an important role during embryo transfer (ET). In clinical practice, luteal phase support progesterone supplementation is systematically offered to all women undergoing medically assisted procreation (AMP), independently of ET conditions (fresh and frozen).

The investigators propose to perform a prospective cross-sectional single-center cohort study to measure progesterone levels on the day of the ET on all AMP cycles and to compare these levels between active pregnancies and ET unsuccessful cycles. They will determine progesterone threshold levels corresponding to successful attempts in all ET strategies (fresh and frozen) as well as clinical and biological risk factors leading to luteal phase deficiency during ET. They could therefore individualize progesterone supplementation according to patient's needs.

Enrollment: 250 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• planned embryo transfer
• signed informed consent

Exclusion criteria

• patients falsely included, major inclusion criteria not respected
• lack of social insurance
• refusal to participate in the research

Trial design

250 participants in 1 patient group

serum progesterone measurement

Treatment:

Other: serum progesterone measurement