Impact of Sleep Apnea on Sepsis Mortality

Taipei Veterans General Hospital

Status: Unknown

Conditions: Mortality; Sleep Apnea Syndromes; Sepsis

Treatments: Biological: OSA

Study type: Observational

Funder types: Other

Identifiers

NCT03654456

2018-06-019AC

Details and patient eligibility

About

By clinical record review, this retrospective study aims to compare the mortality of sepsis patients with versus without obstructive sleep apnea, who were diagnosed and treated in Taipei Veterans General Hospital, Taiwan.

Full description

This retrospective study aims to compare the mortality of sepsis patients with versus without obstructive sleep apnea (OSA). Patients with a diagnosis of sepsis, who had received a prior polysomnography at Taipei Veterans General Hospital during Jan. 1, 2001 to May 31, 2017 will be enrolled. Obstructive sleep apnea (OSA) is defined by an apnea-hypopnea index at least 5/hr with compatible symptoms. Their clinical record will be reviewed and data including demography, polysomnography and details related to sepsis (source of infection, number of organ dysfunction at initial diagnosis of sepsis and survival time) will be collected. The start of the survival time (follow-up time) is the date when sepsis is diagnosed. The end of the survival time (follow-up time) is the date of death or end of hospitalization (date of discharge). Survival analyses will be performed.

Enrollment: 280 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients who received received a polysomnography at Taipei Veterans General Hospital during Jan. 1, 2001 to May 31, 2017
2. Patients who were admitted with a diagnosis of sepsis after the polysomnography
3. The diagnosis of sepsis fulfilling the clinical criteria

Exclusion criteria

1. Younger than 20 years
2. Not compatible with a definition of sepsis
3. subjects with incomplete data

Trial design

280 participants in 2 patient groups

Sepsis patients with OSA

Description:

Sepsis patients who received a prior polysomnography showing an apnea-hypopnea index at least 5/hr with compatible symptoms

Treatment:

Biological: OSA

Sepsis patients without OSA

Description:

Sepsis patients who received a prior polysomnography showing an apnea-hypopnea index less than 5/hr