Impact of Sleep Restriction on Blood Pressure Reactivity

University of Missouri (MU)

Status: Enrolling

Conditions: Blood Pressure; Sleep

Treatments: Behavioral: Sleep Restriction

Study type: Interventional

Funder types: Other

Identifiers

NCT07489417

2132616

Details and patient eligibility

About

The purpose of the research study is to examine the effects of shortened sleep on blood pressure.

Enrollment: 45 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adult men and women
• 18-45 years of age
• BMI < 25 kg/m² (normal weight group) or ≥ 30 kg/m² (obesity group)
• Non-pregnant, non-breastfeeding, and non-nicotine users
• Self-reported history of normal sleep duration (7-9 hours/night) and bedtime prior to midnight
• Premenopausal

Exclusion criteria

• No acute or chronic conditions
• Taking no medications known to affect sleep, autonomic, metabolic, or cardiovascular function
• Self-reported history of irregular sleep
• Self-reported history of hepatic, renal, pulmonary, cardiovascular, or neurological disease, stroke or neurovascular disease, bleeding/clotting disorders, sleep apnea or other sleep disorders, diabetes, history of alcoholism or substance abuse, major cardiovascular event or surgical procedure within the past three months, or hypertension

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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45 participants in 2 patient groups

Sleep Restriction

Experimental group

Description:

You will be asked to shorten your sleep to four hours.

Treatment:

Behavioral: Sleep Restriction

Normal Sleep

No Intervention group

Description:

You will be asked to sleep for 7-9 hours.