Impact of Sleep Restriction on Performance in Adults

Columbia University

Status: Completed

Conditions: Obesity; Sleep Restriction; Sleep

Treatments: Behavioral: Sleep Restriction (SR)

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT02960776

1R01HL128226-01A1 (U.S. NIH Grant/Contract)

AAAQ7746

Details and patient eligibility

About

The overall goal of this project is to look at the effects of long-term, sustained sleep restriction (SR) in adults, and assess the effects on mood and cognitive and physical performance.

Full description

Chronic Sleep Restriction (SR) is highly prevalent in today's modern society. Artificial light, portable electronic devices, and 24-h services have allowed individuals to remain active throughout the night, leading to reductions in sleep duration. SSD has been linked to obesity and our laboratory has been interested in establishing whether sleep could be a causal factor in the etiology of obesity. Given the increasing prevalence of obesity over the past 5 decades, coinciding with the marked reduction in sleep duration, further exploration into the role of sleep as a risk factor for obesity could provide additional ammunition in the fight to prevent further increases in the incidence of obesity.

This study will be a randomized, crossover, outpatient SR study with 2 phases of 6 weeks each, with a 6 week wash-out period between the phases. Sleep duration in each phase will be the participant's regular bed- and wake times during the habitual sleep (HS) phase and HS minus 1.5 hours in the SR phase. During the HS phase, participants will be asked to follow a fixed bedtime routine based on their screening sleep schedule. During the SR phase, participants will be asked to keep their habitual wake time constant but delay their bedtime to achieve a reduction of 1.5 hours in total sleep time.

Enrollment: 45 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 25-29.9 kg/m2
• Have at least one obese parent
• Habitually sleep 7-9 hours a night
• Free of any current and past sleep and psychiatric disorders, including eating disorders, diabetes or Cardiovascular disease (CVD) (i.e., normal scores on: Pittsburgh Quality of Sleep Questionnaire Epworth Sleepiness Scale, Berlin Questionnaire, Sleep Disorders Inventory Questionnaire, Beck Depression Inventory, Composite Scale of Morningness/Eveningness, Three Factor Eating Questionnaire)
• All racial/ethnic groups

Exclusion criteria

• Smokers (any cigarettes or ex-smoker < 3 years)
• Neurological, medical or psychiatric disorder
• Diabetics
• Eating and/or sleep disorders
• Contraindications for MRI scanning
• Travel across time zones within 4 weeks
• History of drug and alcohol abuse
• Shift worker (or rotating shift worker)
• Caffeine intake > 300 mg/d
• Heavy equipment operators
• Commercial long-distance drivers

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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45 participants in 2 patient groups

Habitual Sleep (HS)

No Intervention group

Description:

Participants will be asked to follow a fixed bedtime routine based on the participant's regular bed- and wake-times during the habitual sleep (HS) phase.

Sleep Restriction (SR)

Experimental group

Description:

Participants will be asked to keep their habitual wake time constant but delay their bedtime to achieve a reduction of 1.5 hours in total sleep time during the sleep restriction (SR) phase.

Treatment:

Behavioral: Sleep Restriction (SR)