Impact of Slowly Digestible Carbohydrates on the Gut-brain Axis

Purdue University

Status: Completed

Conditions: Appetitive Behavior; Obesity; Diabetes Mellitus, Type 2

Treatments: Other: Chickpea flour + epigallocatechin gallate (EGCG); Other: Waxy potato starch + epigallocatechin gallate (EGCG); Other: Alternanoligosaccharide 15; Other: Rice flour; Other: Inulin; Other: Waxy potato starch

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT05349903

IRB-2020-986

Details and patient eligibility

About

Our laboratory is investigating the physiological outcomes and health benefits of the consumption of high-quality carbohydrates. One important aspect of the high-quality carbohydrate characteristics is a slow and sustained digestion and glucose release to the blood. In the proposed study, the investigators will evaluate the consumption of different types of slowly digestible carbohydrates (SDCs) and their beneficial effects including moderation of the glycemic response profile (postprandial glycemic response, PPGR) and stimulation of the gut-brain axis, which controls appetite and food intake. This stimulation will be evaluated in terms of second-meal food intake and the circulatory level of appetite-suppressing gut hormones (such as glucagon-like peptide-1).

Enrollment: 20 patients

Sex: All

Ages: 22 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 18.5 - 25 kg/m2
• Stable weight for the past 3 months (i.e. +/- 2..5 kg)

Exclusion criteria

• Pregnant or nursing women
• Diabetic
• Individuals with history of gastrointestinal disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

20 participants in 6 patient groups

Rice flour

Experimental group

Description:

Rapidly digestible control

Treatment:

Other: Rice flour

Alternanoligosaccharide 15

Experimental group

Treatment:

Other: Alternanoligosaccharide 15

Waxy potato starch

Experimental group

Treatment:

Other: Waxy potato starch

Combination of waxy potato starch and epigallocatechin gallate (EGCG)

Experimental group

Treatment:

Other: Waxy potato starch + epigallocatechin gallate (EGCG)

Combination of chickpea flour and epigallocatechin gallate (EGCG)

Experimental group

Treatment:

Other: Chickpea flour + epigallocatechin gallate (EGCG)

Inulin

Experimental group

Treatment:

Other: Inulin