Impact of Sperm DNA Integrity on In Vitro Cycles (TBA on IVF)

Northwell Health

Status: Completed

Conditions: Male Infertility; Unexplained Infertility; Abortion, Habitual

Study type: Observational

Funder types: Other

Identifiers

NCT01232465

10-249A

Details and patient eligibility

About

Sperm DNA integrity will be measured via the Toluidine Blue Assay (TBA) for patients undergoing In Vitro Fertilization (IVF); the study will determine correlations, if any, between IVF success and sperm DNA integrity.

Enrollment: 420 patients

Sex: Male

Volunteers: No Healthy Volunteers

Inclusion criteria

• couple undergoing IVF at the Center for Human Reproduction
• sperm sample given from partner (not a donor)

Exclusion criteria

• low sperm concentration (<5 million/cc)
• using a donor sample

Trial design

420 participants in 2 patient groups

IVF

Description:

those individuals undergoing conventional IVF to inseminate their retrieved eggs

ICSI

Description:

those individuals whose eggs were fertilized via intracytoplasmic sperm injection (ICSI)