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Impact of Spices and Herbs on Endothelial Function

L

Laval University

Status

Completed

Conditions

Endothelial Function

Treatments

Dietary Supplement: Ginger
Dietary Supplement: Oregano
Dietary Supplement: Cinnamon
Dietary Supplement: Placebo
Dietary Supplement: Black pepper
Dietary Supplement: Rosemary

Study type

Interventional

Funder types

Other

Identifiers

NCT01085019
INAF-2009-253

Details and patient eligibility

About

The general objective of the study is to investigate the effects of the daily consumption of spices and herbs for four (4) consecutive weeks in endothelial function and cardiovascular risk factors of men and postmenopausal women.

Full description

The purpose is to assess whether the polyphenol/antioxidant content of different spices will affect endothelial function and other cardiovascular risk factors.

Enrollment

224 patients

Sex

All

Ages

40 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Age 40-70 yrs
  • Men and postmenopausal women
  • Waist girth >102cm (men) or >88cm (women)
  • LDL-C > 2.8 mmol/L
  • Framingham 10-yr risk score < 10%
  • Marginal endothelial dysfunction
  • Non smoker

Exclusion criteria

  • Medication for lipid, hypertension, diabetes
  • History of CVD, diabetes, other endocrines disorders
  • Pre-menopausal women
  • Alcohol consumption > 1 drink per day
  • Unusual dietary habits (e.g. vegetarism)
  • Chronic use of supplements (estrogens, vitamins, minerals or flavonoids)
  • Aversion or intolerance for spices and/or herbs
  • Injury to fingers or amrs that would interfere with endothelial function measurement

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

224 participants in 6 patient groups, including a placebo group

Dietary supplement: Cinnamon
Experimental group
Treatment:
Dietary Supplement: Cinnamon
Dietary supplement: Oregano
Experimental group
Treatment:
Dietary Supplement: Oregano
Dietary supplement: Ginger
Experimental group
Treatment:
Dietary Supplement: Ginger
Dietary supplement: Rosemary
Experimental group
Treatment:
Dietary Supplement: Rosemary
Dietary supplement: Black pepper
Experimental group
Treatment:
Dietary Supplement: Black pepper
Dietary supplement: Placebo
Placebo Comparator group
Treatment:
Dietary Supplement: Placebo

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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