Impact of Sprint Stair Climbing "Snacks" on Markers of Metabolism and Vascular Function

University of British Columbia

Status: Completed

Conditions: Physical Activity; Diet Modification

Treatments: Behavioral: Low-carbohydrate Sedentary; Behavioral: High-Carbohydrate Active; Behavioral: High-Carbohydrate Sedentary

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03374436

H17-01747

Details and patient eligibility

About

Prolonged sitting has been shown to impair metabolism and vascular function. The overall purpose of this study is to determine if breaking up prolonged (9 hours) of sitting with brief (~20 second) stair climbing exercise "snacks" can improve markers of metabolic control and vascular health in healthy young male participants and in males or females with overweight/obesity who are at risk of insulin resistance. An additional purpose is to determine if saliva insulin can be used as a valid indicator of blood insulin when measured throughout the day in sedentary and active conditions and when diets with different amounts of carbohydrates are consumed.

Enrollment: 23 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Lean Group Inclusion Criteria:

Non-smoking

Lean Group Exclusion Criteria:

Diagnosed with diabetes or prediabetes (fasting blood sugar more than 6.0 mmol/l) or any other chronic condition that may impact glucose or insulin levels.

BMI is over 25 kg/m2 Take medications which may affect glucose and insulin levels Allergic to eggs. Smoker Competitive or serious endurance athlete.

Overweight/Obese Group Inclusion Criteria:

Elevated waist circumference (>102 cm for male and >88 cm for female)

Overweight/Obese Group Exclusion Criteria:

Diagnosed with diabetes (fasting blood sugar more than 7.0 mmol/l) Take medications which may affect glucose and insulin levels Allergic to eggs. Smoker Competitive or serious endurance athlete.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

23 participants in 3 patient groups

High-Carbohydrate Sedentary

Experimental group

Description:

Participants will remain seated for 9 hours (except for using the restroom) while consuming a high-carbohydrate diet (3 meals)

Treatment:

Behavioral: High-Carbohydrate Sedentary

High-Carbohydrate Active

Experimental group

Description:

Participants will remain seated for 9 hours (except for using the restroom) while consuming a high-carbohydrate diet (3 meals) but will complete 8 stair climbing sprint "snacks" once per hour involving ascending 3 flights of stairs at a vigorous pace (\~20 seconds each).

Treatment:

Behavioral: High-Carbohydrate Active

Low-Carbohydrate Sedentary

Active Comparator group

Description:

Participants will remain seated for 9 hours (except for using the restroom) while consuming a low-carbohydrate diet (3 meals)

Treatment:

Behavioral: Low-carbohydrate Sedentary