Impact of Sub-anesthetic Dose of Ketamine on Post Spinal Hypotension in Caesarean Delivery

Ain Shams University

Status and phase: Completed; Phase 4

Conditions: Anesthesia

Treatments: Drug: Ketamine; Drug: isotonic saline

Study type: Interventional

Funder types: Other

Identifiers

NCT03624166

FAMUS R 38/ 2018

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of sub anesthetic dose of ketamine on vasopressor (Ephedrine) requirement to prevent maternal hypotension after spinal anesthesia in caesarean section.

Enrollment: 80 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Physical status American Society of Anesthesiologist(ASA) I or II. Full term pregnancy

Exclusion criteria

• ,Pre-eclampsia.
• Chronic hypertension.
• Cardiovascular troubles.
• any contraindications to spinal anesthesia as back infection , coaguolopathy , patient refusal

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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80 participants in 2 patient groups, including a placebo group

Ketamine

Active Comparator group

Description:

sub- anesthetic dose of ketamine 0.5 mg/kg will be given in 3 ml volume

Treatment:

Drug: Ketamine

isotonic saline

Placebo Comparator group

Description:

isotonic saline 3 ml volume will be given

Treatment:

Drug: isotonic saline