Impact Of Subclinical Hypothyroidism On Short-Term Outcomes In Patients With Acute Coronary Syndrome In Sohag University Hospitals

Sohag University

Status: Enrolling

Conditions: Subclinical hypothyroïdism; Acute Coronary Syndrome

Treatments: Diagnostic Test: cardiac enzymes; Diagnostic Test: ECG; Diagnostic Test: thyroid function tests

Study type: Observational

Funder types: Other

Identifiers

NCT06409520

soh-Med-24-04-04MD

Details and patient eligibility

About

Introduction:

Subclinical hypothyroidism (SCH) is defined biochemically as a normal serum free thyroxine (T4) level in the presence of an increased serum thyroid stimulating hormone (TSH) concentration.(1) Its prevalence ranges from 4 to 15 percent and is higher in females and increasing age.(2) Overt hypothyroidism was associated with accelerated atherosclerosis and an increased risk of cardiovascular abnormalities. (3) Some studies have reported a higher atherosclerotic cardiovascular disease risk in patients with SCH. (5-8) Elevated TSH levels were observed to be associated with higher cholesterol levels.(9) Higher mortality was also reported in some studies (6,10) especially with TSH ≥ 10.0 mIU/L, in contrast to other studies.(11,12) Heart failure events and myocardial infarction have been reported to be higher.(13,14) These findings in SCH patients could be explained by mitochondrial oxidative stress due to elevated inflammatory markers, hypercoagulability, endothelial dysfunction, insulin resistance, increased vascular resistance and left ventricular diastolic and systolic dysfunction.(3,15,16) As is the case with overt hypothyroidism, SCH was observed to be associated with elevated peripheral vascular resistance and diastolic dysfunction.(17) There are a few studies evaluating the effects of subclinical hypothyroidism on the outcomes of acute coronary syndrome patients.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients (age ≥18 years) diagnosed with acute coronary syndrome

Exclusion criteria

1. Patients with overt hypothyroidism or hyperthyroidism.
2. Pregnant and lactating females
3. Patients with severe comorbid conditions e.g. Malignancy decompensated liver diseases or end stage kidney diseases.
4. Patients with a history of taking medications affecting thyroid function

Trial design

200 participants in 2 patient groups

Group (1)

Description:

patients with acute coronary syndrome and subclinical hypothyroidism

Treatment:

Diagnostic Test: ECG

Diagnostic Test: cardiac enzymes

Diagnostic Test: thyroid function tests

Group (2)

Description:

(control group) patients with acute coronary syndrome and normal thyroid function

Treatment:

Diagnostic Test: ECG

Diagnostic Test: cardiac enzymes

Diagnostic Test: thyroid function tests