Impact of Surgical Management for Relapse After Conversion Hepatectomy for Initially Unresectable Colorectal Liver Metastasis

Fudan University

Status: Completed

Conditions: Liver Metastases; Colorectal Cancer

Treatments: Procedure: Non-Repeat Liver Surgery; Procedure: Repeat Liver Surgery

Study type: Observational

Funder types: Other

Identifiers

NCT05462470

IU-CRLM

Details and patient eligibility

About

For patients with initially unresectable colorectal liver metastasis (IU-CRLM) receiving effective conversion therapy, disease relapse after conversion hepatectomy is common due to the extensive tumor load. Yet, few studies have focused on the assessment and management of relapse after conversion hepatectomy for IU-CRLM. This study aimed to investigate the impact of surgical management for relapse after conversion hepatectomy in IU-CRLM.

Enrollment: 255 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• initially unresectable colorectal liver metastasis (IU-CRLM)
• received conversion therapy
• underwent conversion hepatectomy

Exclusion criteria

• the histologic type of CRLM was not called adenocarcinoma
• uncontrollable extrahepatic metastases, such as peritoneal, bone, brain metastasis
• history of previous hepatectomy
• the primary tumor was not resected or palliative resection
• R1 or R2 liver resection

Trial design

255 participants in 2 patient groups

repeat liver surgery

Description:

repeat liver surgery for liver relapse lesions

Treatment:

Procedure: Repeat Liver Surgery

non-repeat liver surgery

Description:

non-repeat liver surgery, just only systemic palliative chemotherapy

Treatment:

Procedure: Non-Repeat Liver Surgery