Impact of Systemic Corticosteroid Therapy on Lens Transparency and Quantification of Lens Autofluorescence.

University Hospital, Clermont-Ferrand

Status: Completed

Conditions: Patients With Systemic Inflammatory Diseases Receiving for the First Time a Protracted General Corticostroid Therapy

Treatments: Drug: Prednisolone

Study type: Interventional

Funder types: Other

Identifiers

NCT00337623

CHU63-0011

Details and patient eligibility

About

Corticosteroid therapy is usually regarded as a risk factor for the development of posterior subcapsular cataracts but prospective studies on this topic and accurate assessment of this potential adverse effect are lacking. We will evaluate changes of lens transparency after administration of systemic corticosteroid therapy for at least one year with Scheimpflug photography and quantification of lens autofluorescence.

Full description

Corticosteroid therapy is usually regarded as a risk factor for the development of posterior subcapsular cataracts but prospective studies on this topic and accurate assessment of this potential adverse effect are lacking. We will evaluate changes of lens transparency after administration of systemic corticosteroid therapy for at least one year with Scheimpflug photography and quantification of lens autofluorescence.

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient who starts a treatment with Prednisone, Prednisolone or Methylprednisolone for an Expected time of one year at least, with normal lens autofluorescence at inclusion.

Exclusion criteria

• Previous cataracts and abnormal increase of lens autofluorescence considering age
• Previous elevation of intraocular pressure
• Progressive inflammatory or non inflammatory ocular disease
• Eye drop except artificial tears
• Insulin dependent and non insulin dependent diabetes
• Atopic dermatitis
• Previous protracted corticosteroid therapy
• Drugs known to be associated with an increased risk of cataract

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)