Impact of Tachycardia on Outcome After Subarachnoid Hemorrhage (SAH)

Columbia University

Status: Terminated

Conditions: Tachycardia; Subarachnoid Hemorrhage (SAH)

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01585311

AAAA5384

Details and patient eligibility

About

The purpose of this retrospective study is to test the hypothesis that uncontrolled tachycardia serves as a risk factor for adverse cardiovascular events and poor outcome after Subarachnoid Hemorrhage (SAH).

Full description

The design of the current study will be to conduct a retrospective analysis of prolonged heart rate and uncontrolled tachycardia using patients enrolled in the investigators prospective observational cohort study since the electronic medical record systems have been implemented. The investigators know that there have been periods when these electronic systems have failed, resulting in lost data. The investigators anticipate retrospective collection of hourly heart rate for approximately 400 SAH patients that will have ICU data and 3 month modified Rankin documented in our Subarachnoid Hemorrhage Outcomes Project (SHOP) database. The investigators will determine what percent of them have prolonged elevated heart rate and tachycardia. Prolonged heart rate and uncontrolled tachycardia has been defined as a heart rate greater than 95 for greater than 12 hours in one 24 hour period of their ICU stay. The investigators will conduct a ROC curve analysis to determine the appropriate heart rate and duration thresholds that are most predictive of poor prognosis after SAH. Patients be will stratified based on several criteria including admission coma score, early (SAH day 0 to 3) or late (SAH day >=4) ICU admission, presence of intraventricular hemorrhage on admission CT, history of beta-blocker usage, age, and gender.

Enrollment: 1,540 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >=18 years
• Diagnosis of subarachnoid hemorrhage established by computed tomography (CT scan) or xanthochromia of the cerebrospinal fluid if the CT is negative
• Written informed consent from either the patient or a family member
• Admitted to the NICU for at least 12 hours

Exclusion criteria

• Age < 18yrs
• traumatic SAH
• SAH due to a rupture of an arteriovenous malformation, neoplasm vasculitis or other secondary causes

Trial design

1,540 participants in 1 patient group

Subarachnoid Hemorrhage patients

Description:

SAH patients with hourly eMR values of Heart Rate