Impact of tDCS on Cerebral Autoregulation

Charité University Medicine Berlin

Status: Completed

Conditions: Migraine With Aura; ICA Stenosis; Cerebral Microangiopathy; CADASIL

Treatments: Device: sham tDCS; Device: Anodal tDCS; Device: Cathodal tDCS

Study type: Interventional

Funder types: Other

Identifiers

NCT01865604

tDCS_cVMR

Details and patient eligibility

About

The aim of the study is to investigate whether there is a polarity-specific influence of tDCS on cerebral vasomotor reactivity monitored by transcranial doppler sonography.

Enrollment: 60 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. severe cerebral Microangiopathy
2. NOTCH3 carrier
3. Migraine with aura (IHS Classification ICHD-II)
4. Stenosis >80%, ECST-Criteria

Exclusion criteria

• seizure disorder
• history of severe alcohol or drug abuse, psychiatric illness like severe depression, poor motivational capacity
• dementia

(1+2) history of stroke in past 3 months (3) migraine prophylaxis (4) contralateral stenosis >50%,

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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60 participants in 3 patient groups

Anodal tDCS

Experimental group

Description:

anaodal transcranial direct current stimulation

Treatment:

Device: Anodal tDCS

Cathodal tDCS

Active Comparator group

Description:

cathodal transcranial direct current stimulation

Treatment:

Device: Cathodal tDCS

Sham tDCS

Sham Comparator group

Description:

no stimulation

Treatment:

Device: sham tDCS