Impact of the Blood Culture Technique on the Diagnosis of Infective Endocarditis (UniEndo)

Central Hospital, Nancy, France

Status: Completed

Conditions: Bacteremia; Infective Endocarditis

Treatments: Procedure: Blood Culture

Study type: Observational

Funder types: Other

Identifiers

NCT03153384

APJ2015/UNIENDO-GOEHRINGER/SKJ

Details and patient eligibility

About

To evaluate the performance of a single high volume blood culture sampling strategy versus the actually used multiple sampling strategy for the diagnosis and categorization of infective endocarditis according to the Duke-Li classification in a Population of adults suspected of infective endocarditis.

Enrollment: 269 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients older than 18 years
• Suspected endocarditis: Patients with Duke-Li-ESC 2015 classification as a major morphological criterion or at least two minor criteria, other than a microbiological criterion, will be considered suspicious of infectious endocarditis.
• Not objecting to their inclusion in the study after delivery and explanation of the information form.
• Absence of microbiological documentation sought or available at the time of inclusion (a patient having already had negative blood cultures or being identified during the screening can be included).

Exclusion criteria

• Antibiotherapy adapted to a situation of endocarditis, introduced more than 24 hours or stopped for less than 7 days in case of therapeutic window.
• Any previous antibiotic therapy in the 7 days preceding the inclusion leading to an improvement in the clinical symptomatology.
• State of consciousness not allowing loyal information.

Trial design

269 participants in 1 patient group

one both experimental and control arm

Description:

Each patient experiences two methods of blood cultures.

Treatment:

Procedure: Blood Culture