Impact of the Contamination Mode on the Clinical Evolution During Pseudomonas Aeruginosa Ventilator Acquired Pneumonia (PYO GEN)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Ventilation Acquired Pneumonia; Pseudomonas Aeruginosa

Study type: Observational

Funder types: Other

Identifiers

NCT01745796

12SC02

Details and patient eligibility

About

Pseudomonas aeruginosa is the main pathogen of nosocomial respiratory infections. Its increasing resistance to antibiotics requires the development of new strategies for prevention and control, demanding a better understanding of the modes of transmission and evolutionary dynamics of this bacteria. In patients under invasive mechanical ventilation, the main mode of contamination by Pseudomonas remains debated, with 3 modes of contamination (endogenous, crossed transmission between patients, or environmental origin) of varying importance, mainly depending on the endemic situation of the place of study.

The emergence of new genotyping technologies (DiversiLab) can now facilitate studies of molecular epidemiology. Thanks to the multidisciplinary collaboration and innovative techniques, the investigators wish to study the impact of the mode of contamination on the outcome of ICU patients, intubated and ventilated for more than 72 hours.

Full description

The presence of environmental reservoirs can cause infections and multidrug-resistant P. aeruginosa colonization with P. aeruginosa is itself a prognostic factor, but the impact of the route of infection on the evolution of the history and future of the infectious patient is not established.

A second factor that may influence the evolution infectious is the degree of genetic heterogeneity of the bacterial population. Multiple exposure pathways could also influence the genetic diversity.

Enrollment: 77 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients> 18 years
• hospitalized in the intensive care unit
• with more than 72 hours of mechanical ventilation
• Presenting a positive bacteriological sample P. aeruginosa.

Exclusion criteria

• Minors.
• Pregnant or lactating women.
• Patients under guardianship, under judiciary placement, or hospitalized without their consent.
• Patients not affiliated to a social security scheme.
• Long-term corticosteroid therapy (> 2mg/kg or> 1 month before the onset of established infection suspected)
• Ongoing chemotherapy, AIDS, transplant patient under immunosuppressive drugs.
• Bedridden patient or therapeutic decision at ICU arrival

Trial design

77 participants in 1 patient group

Intubated ICU patients