Impact of the COVID-19 Pandemic on Central Precocious Puberty: a Retrospective Cohort Study from Turkey (COVID-19-PP)

Umraniye Education and Research Hospital

Status: Completed

Conditions: COVID19- Infection with SARS-CoV-2 Virus

Study type: Observational

Funder types: Other

Identifiers

NCT06823076

406240

Details and patient eligibility

About

Objective: This study investigates the clinical and demographic characteristics of girls diagnosed with central precocious puberty (CPP) in the pre-pandemic and pandemic periods to assess potential changes during the COVID-19 pandemic.

Full description

Methods: A retrospective cohort study was conducted on patients admitted to the Pediatric Endocrinology Departments of two centers in Turkey. Girls treated with GnRH analogs between March 2018 and 2022 were categorized into two groups: the pre-pandemic group (2018-2020) and the pandemic group (2020-2022). Clinical, anthropometric, and hormonal data were analyzed. Patients with organic lesions, genetic conditions, or medications affecting puberty were excluded.

Enrollment: 192 patients

Sex: Female

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria (Who Can Participate?)

Girls: Tanner stage ≥2 before age 8 peak LH > on gnrh analog test, basal Lh >0,3

Patients with organic lesions (e.g., hypothalamo-pituitary tumors), congenital malformations, oncological diseases, neurosurgical or genetic disorders, or medications affecting puberty were excluded from the study

Trial design

192 participants in 1 patient group

prepandemic and pandemic precocious puberty groups were compared