Impact of the Olfactory Stimulation on the People With Mild Dementia Via the Horticultural Therapy

National Taiwan Normal University

Status: Completed

Conditions: Dementia

Treatments: Other: board game comparison; Other: olfactory stimulation intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT05168098

201901HM030 (Other Identifier)

MOST 108-2410-H-003-128-

Details and patient eligibility

About

The aim of this study is to examine the effect of the olfactory stimulation intervention on the people with mild to moderate dementia. We recruit 28 participants who has been diagnosed with mild to moderate dementia from 2 day care centers in Taipei. They are randomly assigned to three groups, including the olfactory intervention group, game comparison group, and control group. Beside the control group, the participant with two other groups were required to attend twelve weeks intervention (twice a week, thirty minutes for one section). Every participants completed the olfactory test, both paper-pencil and computer-based examination for cognition, blood test and psychological measurement before and after the intervention. The results showed that the participant in olfactory intervention group significant improved score in the LOTCA-G examination, and the Aβ1-42 concentration of the blood test significant increase in the control group; furthermore, the olfactory intervention group is lowest concentration among three groups in the Tau concentration of the blood test via ANCOVA analysis.

Enrollment: 28 patients

Sex: All

Ages: 50 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ages >50 years with a diagnosis of mild or moderate dementia
• being admitted to the day care center and living in the community
• being willing to do blood test with a family member's consent.

Exclusion criteria

• experience in chronic rhinitis or sinusitis, which causes loss of smell; inability to perform the cognitive exam or olfactory test (e.g., having a severe hearing impairment)
• inability to attend group activities due to severe emotional or aggressive behaviors

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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28 participants in 3 patient groups

olfactory intervention group

Experimental group

Treatment:

Other: olfactory stimulation intervention

game comparison group

Active Comparator group

Treatment:

Other: board game comparison

control group

No Intervention group