Impact of Three Different Gonadotrophin Regimes on Egg Donation Program

Instituto Valenciano de Infertilidad, IVI VALENCIA

Status and phase: Completed; Phase 4

Conditions: Ovarian Stimulation

Treatments: Drug: r-FSH plus HP-hMG; Drug: r-FSH; Drug: HP-hMG

Study type: Interventional

Funder types: Other

Identifiers

NCT00829075

VLC-MM-0501-37

Details and patient eligibility

About

Exploratory study assessing the effect of three gonadotrophin protocols on Controlled Ovarian Stimulation (COS) parameters and IVF outcome in oocyte donors undergoing GnRH analogue (long protocol). 1,028 donors were randomized in three groups: Group I (n= 346) only r-FSH, Group II (n= 333) only HP-hMG and Group III (n= 349) r-FSH plus HP-hMG. IVF outcome of 1,059 oocyte recipients was compared.

Sex: Female

Ages: 18 to 34 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy women 18-34 years of age
• regular menstrual cycles
• no family history of hereditary or chromosomal diseases
• normal karyotype
• BMI 18-29 Kg/m2
• negative screening for sexually transmitted diseases

Exclusion criteria

• women with PCOS were not included in this study

Trial design

0 participants in 3 patient groups

I

Experimental group

Description:

only r-FSH TREATMENT

Treatment:

Drug: r-FSH

II

Experimental group

Description:

only HP-hMG TREATMENT

Treatment:

Drug: HP-hMG

III

Experimental group

Description:

r-FSH plus HP-hMG TREATMENT

Treatment:

Drug: r-FSH plus HP-hMG