Impact Of Timing Of Drainage Of Massive Ascites On Operative And Post-Operative Course In Living-Donor Liver Transplant Recipients. A Prospective Randomized Controlled Trial. (AscitesLDLT)

Mansoura University

Status: Completed

Conditions: Massive Ascites

Treatments: Procedure: operative drainage of ascites through small skin incision after induction of anesthesia; Device: ultrasound; Procedure: ultrasound guided ascitic fluid drainage

Study type: Interventional

Funder types: Other

Identifiers

NCT02867293

Ascites

Details and patient eligibility

About

Massive ascites is usually controlled over several weeks pre-operatively in liver transplant recipients with the risk of encephalopathy and peritonitis. We hypothesized that intra-operative drainage of ascites will be safe and avoids the inherent risks of pre-operative drainage.

Enrollment: 80 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• liver transplant candidates with tense acsites

Exclusion criteria

• severe coagulpathy (INR more than 2 or platlet count less than 50) MELD more than 20

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups

Preop-drainage

Active Comparator group

Description:

ascites drained over the pre-operative week through multiple ultrasound guided paracentesis

Treatment:

Procedure: ultrasound guided ascitic fluid drainage

Device: ultrasound

Op-drainage

Active Comparator group

Description:

ascetic fluid drained through an abdominal incision after anesthesia

Treatment:

Procedure: operative drainage of ascites through small skin incision after induction of anesthesia