Impact of Timing of PD Assessments on Measures of Platelet Reactivity in Patients Undergoing PCI Treated With Cangrelor

University of Florida

Status: Completed

Conditions: Coronary Artery Disease

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT04668495

Cangrelor Timing

Details and patient eligibility

About

This study is assessing the impact of timing of PD assessments on measures of platelet reactivity in patients undergoing PCI treated with cangrelor.

Full description

Cangrelor is characterized by reversible binding to the P2Y12 receptor and is promptly inactivated through dephosphorylation by ectonucleotidase leading to its very short plasma half-life. Consequently the timing at which PD assessments are performed after blood sample collection may impact measures of platelet reactivity in patients treated with cangrelor. We therefore hypothesize that measures of platelet inhibitory effects observed in cangrelor treated patients will reduce with time following blood sampling.

Enrollment: 17 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years old
• CAD patients (stable CAD, NSTE-ACS, or STEMI) undergoing PCI and treated with cangrelor per standard of care.
• Treated with aspirin prior to the PCI procedure per standard of care

Exclusion criteria

• Treatment with an oral P2Y12 inhibitor (clopidogrel, prasugrel or ticagrelor) within past 10 days
• Treatment with oral anticoagulation (vitamin K antagonist, dabigatran, apixaban, rivaroxiban) within past 3 days
• Treatment with a glycoprotein IIb/IIIa inhibitor during PCI
• Fibrinolytics within 48 hours
• Known hemoglobin<10 gm/dL
• Known platelet count <80x106/mL
• Active bleeding or hemodynamic instability
• Known end stage renal disease on hemodialysis
• Known severe hepatic dysfunction

Trial design

17 participants in 1 patient group

Cangrelor Group

Description:

This is the study cohort that the blood sample will be obtained from. There are no interventions