Impact of Transcranial Direct Current Stimulation on Language Functions in Mild Cognitive Impairment (STIMCI)

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Charité University Medicine Berlin

Status

Completed

Conditions

Mild Cognitive Impairment

Treatments

Device: tDCS

Study type

Interventional

Funder types

Other

Identifiers

NCT01771211
FL379101

Details and patient eligibility

About

The purpose of this study is to determine if non-invasive electrical brain stimulation can improve word-retrieval in Mild Cognitive Impairment (MCI).

Full description

Previous studies showed that anodal transcranial direct current stimulation (atDCS) can have beneficial effects on word-retrieval in healthy younger and older subjects. The present study aims to extend these findings by assessing whether atDCS can also improve known impairments of word-retrieval in Mild Cognitive Impairment. atDCS will be applied to the left inferior frontal gyrus in a sham controlled cross-over within subjects design. Simultaneous functional magnetic resonance imaging (fMRI) will assess underlying neural effects of the stimulation.

Enrollment

18 patients

Sex

All

Ages

45 to 86 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • right handed
  • German native speakers
  • clinical diagnosis of Mild Cognitive Impairment

Exclusion criteria

  • dementia
  • other current or previous neurological or current psychiatric diseases
  • alcohol or drug abuse
  • MRI contraindication (e.g., magnetic metal, pacemaker, claustrophobia

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Triple Blind

18 participants in 2 patient groups

anodal tDCS
Experimental group
Description:
anodal tDCS will be administered for 20 minutes with 1 milliampere (1 mA) to the left inferior frontal gyrus
Treatment:
Device: tDCS
sham tDCS
Sham Comparator group
Description:
sham tDCS will be administered to the left inferior frontal gyrus
Treatment:
Device: tDCS

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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