Impact of Twice-daily Measurement of Expired CO During Hospitalization on Smoking (CoCHU)

University Hospital Center (CHU)

Status: Terminated

Conditions: Hospitalization; Smoking

Treatments: Other: Minimal control; Other: Twice-daily expired carbon monoxide (CO) measurements

Study type: Interventional

Funder types: Other

Identifiers

NCT03729063

RECHMPL18_0078

Details and patient eligibility

About

The main objective of this study is to show that the repeated (twice-daily) measurement of expired CO during hospitalization helps reduce smoking.

Full description

Smoking in France represents 25 billion euros per year in care, hospitalizations and drugs and 78000 deaths / year are linked to a pathology attributable to this addiction. In addition, active consumption of cigarettes is a destabilizing factor for chronic respiratory diseases. During hospitalization for acute respiratory illness, evaluation of smoking cessation remains declarative. Although stopping advice and possibly nicotine replacement therapy are prescribed, no objective measure of smoking is performed to assess the adequacy of this attitude.

This project aims to objectively evaluate smoking during hospitalization by measuring twice daily exhaled CO. The impact of this intervention on the duration of hospitalization and smoking 3m after initial admission will also be evaluated. Tobacco consumption patterns based on reason for hospital admission and background pathology will be highlighted.

Secondary objectives include:

• To measure the impact of expired CO measurement during hospitalization on the smoking status 1 month and 3 months after initial admission.
• To determine smoking patterns during hospitalization according to reason for admission and background pathology.
• To measure the effect of iterative CO measurement on the duration of stays.
• To measure and compare the quality of life of patients.
• To study the variability of expired CO measurements.

Enrollment: 67 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient hospitalized in pneumology for acute respiratory illness or scheduled hospitalization, for a minimum duration of 48h.
• Signature of informed consent
• Patient able to perform all visits and follow the procedures of the study
• Affiliatedor beneficiary of French social security (national health insurance)

Exclusion criteria

• Subject who can not read and / or write French
• Expected travel that precludes study completion
• Patient in palliative care
• Inability to maintain apnea more than 8 seconds
• Participation in another clinical trial or administration of an off-label drug within 4 weeks prior to inclusion

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Sequential Assignment

Masking: None (Open label)

---

67 participants in 2 patient groups

Twice daily expired CO measurements

Experimental group

Description:

Patients included in this arm will have expired CO measurements every morning and evening during their initial hospitalization.

Treatment:

Other: Twice-daily expired carbon monoxide (CO) measurements

Control

Active Comparator group

Description:

Patients included in this arm will have one expired CO measurement on the morning just after initial hospital admission and a second expired CO measurement one the morning prior to discharge.

Treatment:

Other: Minimal control