Impact of Underlying Renal Disease and Immunosuppressive Regimen on Ovarian Reserve in Renal Patients

Wroclaw Medical University

Status: Completed

Conditions: Ovarian Reserve; Immunosuppression; X-rays; Effects; Anti-Mullerian Hormone Deficiency

Treatments: Diagnostic Test: AMH level measurement

Study type: Observational

Funder types: Other

Identifiers

NCT04762615

451/2018

Details and patient eligibility

About

Aging, renal pathology (eg SLE, ADPKD), X-ray exposition and pharmacological treatments, especially previous strong immunosuppression, may negatively influence the ovarian reserve in childbearing age women. Anti-Müllerian hormone (AMH) is regarded as biomarker for ovarian reserve.

Every female with renal disease regularly menstruating that met exclusion criteria could have participated. The aim was to assess ovarian reserve in female patients with normal menstrual cycle and kidney disease, including kidney transplant recipients.

Enrollment: 153 patients

Sex: Female

Ages: 18 to 44 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Conscious written approval
• Autoimmunological disorder with kidneys affection/ kidney transplant recipient- Regular menstrual cycles
• Age above 18 years old

Exclusion criteria

• Irregular menstrual cycles
• Menopause
• PCOS
• Chemiotherapy or radiotherapy in the past
• Surgical interventions within ovaries
• Hypogonadotropic hypogonadism
• Folliculoma
• Age under 18 years old

Trial design

153 participants in 3 patient groups

Patients with renal pathology treated with immunosuppressive drugs

Description:

Female in reproductive age suffering from renal disease that is or was previously treated with immunosuppressive drugs

Treatment:

Diagnostic Test: AMH level measurement

Patients with renal pathology without treatment

Description:

Control group

Treatment:

Diagnostic Test: AMH level measurement

Patients after renal transplantation taking immunosuppressive drugs

Description:

Female in reproductive age after renal transplantation taking immunosuppressive drugs

Treatment:

Diagnostic Test: AMH level measurement