Impact of Using Mini-Bronchoalveolar Lavage as a Diagnostic Test for Ventilator-Associated Pneumonia

University of California San Francisco (UCSF)

Status: Completed

Conditions: Ventilator-Associated Pneumonia

Treatments: Device: Bronchoalveolar lavage

Study type: Interventional

Funder types: Other

Identifiers

NCT00319644

27831-01

Details and patient eligibility

About

The proposed study will evaluate adult patients admitted to the medical or surgical intensive care units (ICUs) at San Francisco General Hospital (SFGH). On admission, patients will be randomized in a 1:1 manner to the mini-bronchoalveolar lavage (BAL) quantitative culture arm in the setting of suspected ventilator-associated pneumonia (VAP) versus the tracheal aspirate culture arm, which is the current test available at SFGH.

Full description

Patients will be randomized to either Mini-Bal or tracheal aspirate then samples will be taken to the lab for culture. Comparative analysis will then be performed based upon lab results.

Enrollment: 37 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All adult patients (> age 18) admitted to 5E, 5R, and 4E intensive care units and are on the ventilator for greater than 48 hours and expected to remain on the ventilator for awhile
• Study procedures would be performed only in patients clinically suspected of having VAP.

Exclusion criteria

• Severe respiratory distress at the time of suspected VAP defined by:

  • FiO2 ≥ 0.7
  • PEEP ≥ 12

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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37 participants in 2 patient groups

Minibal Arm

Experimental group

Description:

Using Mini bronchoalveolar lavage

Treatment:

Device: Bronchoalveolar lavage

Tracheal Aspirates

No Intervention group

Description:

standard of care for ICU.