Impact of Vitamin C Supplementation on Hospital Outcomes in Children Undergoing Corrective Heart Surgery for Congenital Heart Diseases (RCT)

Cairo University (CU)

Status: Not yet enrolling

Conditions: Congenital Heart Disease (CHD)

Treatments: Other: Vitamin C; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT06789640

MS-588-2023 (Other Identifier)

Details and patient eligibility

About

Vitamin C will be given before admission in the immediate preoperative preceding 7 days (the dose 30 -45 mg per day ) in oral drops preparations

Inflammatory markers including CRP , TLC ,PNI , GPS NLR will be checked on admission and on discharge and compared between cases and controls Hospital length stay will also be compared between the two groups

Enrollment: 20 estimated patients

Sex: All

Ages: Under 7 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children in the first two years who will be for corrective surgery for heart diseases congenital heart diseases
• Pediatric patients whose parents or caregivers agree to be enrolled in the study.
• Risk Adjustment for Congenital Heart Surgery -1 (RACHS-1) for Evaluation of Mortality in Children Undergoing Cardiac Surgery : the first two categories (Thiagarajan and C. Laussen 2015)

Exclusion criteria

• Pediatric patients with associated comorbid conditions.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 2 patient groups, including a placebo group

Interventional

Experimental group

Description:

Vitamin C will be given before admission in the immediate preoperative preceding 7 days (the dose 30 -45 mg per day ) in oral drops preparations Inflammatory markers including CRP , TLC ,PNI , GPS NLR will be checked on admission and on discharge and compared between cases and controls Hospital length stay will also be compared between the two groups

Treatment:

Other: Vitamin C

The control group

Placebo Comparator group

Description:

A placebo will be given before admission in the immediate preoperative preceding 7 days (the dose 30 -45 mg per day ) in oral drops preparations Inflammatory markers including CRP , TLC ,PNI , GPS NLR will be checked on admission and on discharge and compared between cases and controls Hospital length stay will also be compared between the two groups

Treatment:

Other: Placebo