Impact of Vitamin D on Endothelial Function and Blood Biomarkers Including CD28 Null Cells in CKD

St George's, University of London

Status and phase: Completed; Phase 3

Conditions: CKd Patients With Stage 3 and 4

Treatments: Drug: Cholecalciferol

Study type: Interventional

Funder types: Other

Identifiers

NCT02005718

090129

Details and patient eligibility

About

Vitamin D deficiency is common in CKD and assciated with CV complications. Endothelial dysfucntion is common in CKD and is a harbinger of atherosclerosis. The study investigated the impact of Vitamin D on endothelial fucntion and blood biomarkers in CKD.

Enrollment: 36 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CKD 3-4 Age 18-80

Exclusion criteria

• Recent MI, CVA, malignancy active infection active inflammation High calcium already on Viatmin D therapy

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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36 participants in 1 patient group

Vitamin D

Experimental group

Description:

Cholecalciferol 300,000 twice

Treatment:

Drug: Cholecalciferol