Impact of Vitamin D Supplementation on COVID-19 Vaccine Response and IgG Antibodies in Deficient Women. (CoVıD-19)

Ege University

Status: Completed

Conditions: Antibody Hypersensitivity; D Vitamin Deficiency; COVID-19 Pandemic

Treatments: Dietary Supplement: Vitamin D supplement

Study type: Interventional

Funder types: Other

Identifiers

NCT05447065

2021/02

Details and patient eligibility

About

Decreased immunity in individuals causes a decrease in vaccine response, and vitamin D worsens this course. Vitamin D is thought to be a vitamin that can strengthen the innate immune response, inhibit the adaptive system, and modulate the vaccine response.

The effect of vitamin D intake on antibodies was studied.

Enrollment: 33 patients

Sex: Female

Ages: 19 to 23 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The study consisted of young volunteer women who completed 2 doses of COVID-19 vaccines, did not receive the 3rd dose, and spent an average of 65 days over the 2nd dose. Participants were included in the study when IgM value was negative, IgG value was positive, they were not older than 25 years, and serum 25-Hydroxy (25(OH)) vitamin D was below 30 ng/mL.

Exclusion criteria

• In addition, individuals participating in the research who were pregnant, had physician-diagnosed cardiovascular diseases, had kidney or liver failure, and had the chronic obstructive pulmonary disease were not included in the study.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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33 participants in 2 patient groups

Participants using vitamin D supplements

Experimental group

Description:

Participants in the experimental group were given 150,000 IU (10 ml) of vitamin D3 supplementation, and it was used regularly for 2 months. From the first measurement, 2 more measurements were taken, 28 days apart, and a total of 3 measurements were taken from the participants.

Treatment:

Dietary Supplement: Vitamin D supplement

Participants not using vitamin D supplements

No Intervention group

Description:

No supplement was given to the control group. From the first measurement, 2 more measurements were taken, 28 days apart, and a total of 3 measurements were taken from the participants.