Impact of Von Willebrand Factor and Its Multimers on Angiogenesis (WILLANGIO)

Nantes University Hospital (NUH)

Status: Enrolling

Conditions: Von Willebrand Diseases

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT04810702

RC20_0531

Details and patient eligibility

About

The study aims to study the expression of numerous proteins involved in angiogenesis in 70 patients with von Willebrand disease in order to try to identify markers of interest. Secondly, the investigators plan to investigate whether there is a relationship between the proteins tested, the distribution of multimers and the clinical phenotype of the patients, in particular by looking for the presence of bleeding linked to the presence of angiodysplasias.

Enrollment: 90 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

For patients:

• Patient with von Willebrand disease proven by genetic analysis of the VWF gene.
• Lack of treatment that could interfere with angiogenesis.
• Patient informed by an information note sent to his home, with the possibility of objecting to the use of his blood samples in the context of research.

For the control:

• Patient with a normal coagulation report
• Absence of abnormal hemorrhagic symptoms
• Lack of notion of angiodysplasia.
• Lack of treatment that could interfere with angiogenesis.
• Patient informed by an information note sent to his home, with the possibility of objecting to the use of his blood samples in the context of research.

Exclusion criteria

• Patient under guardianship or curatorship.
• Pregnant and lactating women.
• Blood transfusion or treatment with von Willebrand factor concentrates less than 7 days old.
• Treatment which may interfere with angiogenesis.

Trial design

90 participants in 2 patient groups

patients with von Willebrand disease

Treatment:

Other: no intervention

case control

Treatment:

Other: no intervention