Impact of Whey and Soy Protein Ingestion in Conjunction With Energy Restriction in Overweight/Obese Individuals

McMaster University

Status: Completed

Conditions: Obesity

Treatments: Behavioral: Weight loss; Dietary Supplement: Soy; Dietary Supplement: Whey

Study type: Interventional

Funder types: Other

Identifiers

NCT01530646

11-999

Details and patient eligibility

About

It is known that dieting (restricted energy intake) without resistance training leads to a reduced metabolic rate, and the loss of both fat and muscle mass. When exercise is not included in a period of restricted energy intake, the degree to which muscle mass is lost is highly dependent upon protein consumption. Whey protein is a high quality protein isolated from milk and is known to stimulate new protein synthesis for all proteins in your body. Previous research has established that the consumption of whey protein has been correlated with retaining muscle mass while stimulating fat loss. However, the mechanisms behind these findings is still unknown. The purpose of this study is to establish a mechanistic underpinning to the efficacy of whey protein versus soy protein and a carbohydrate control (maltodextrin), in promoting fat mass loss and lean mass retention during a period of short-term controlled dietary energy deficit (-750 kcalories/day).

Enrollment: 42 patients

Sex: All

Ages: 35 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 35 to 55 years old
• Moderately Obese/Overweight (body mass index > 25 and < 42 kg/m2)
• Healthy
• Non-smoker

Exclusion criteria

• Suffer from type 2 diabetes, hyperlipidemia, or thyroid dysfunction
• Taking medications
• Having an unstable weight in the past 4-6 months, or dieting at some time during the past 6 months
• Taking weight loss products or aids (including energy drinks)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

42 participants in 3 patient groups, including a placebo group

Control

Placebo Comparator group

Description:

Carbohydrate \& 750 kcal dietary restriction while they receive a daily supplement (2 x 25 g) of maltodextrin (no protein) for 14 days. Weight loss.

Treatment:

Behavioral: Weight loss

Whey

Experimental group

Description:

Whey protein \& 750 kcal dietary restriction while they receive a daily supplement (2 x 25 g) of WPI for 14 days. Weight loss.

Treatment:

Behavioral: Weight loss

Dietary Supplement: Whey

Soy

Experimental group

Description:

Soy protein \& 750 kcal dietary restriction while they receive a daily supplement (2 x 25 g) of SPC for 14 days. Weight loss.

Treatment:

Dietary Supplement: Soy

Behavioral: Weight loss