Impact of Zinc and Vitamin D3 Supplementation on the Survival of Aged Patients Infected With COVID-19 (ZnD3-CoVici)

University Hospital, Lille

Status: Withdrawn

Conditions: SARS-CoV 2

Treatments: Dietary Supplement: Zinc gluconate; Dietary Supplement: 25-OH cholecalciferol

Study type: Interventional

Funder types: Other

Identifiers

NCT04351490

2020-A00873-36 (Other Identifier)

2020_30

Details and patient eligibility

About

Mortality from Covid-19 increases with age, reaching 14.8% from the age of 80. The severity of the infection is linked to the acute respiratory distress syndrome (ARDS) which requires intensive care. ARDS is the consequence of the reactional inflammatory storm that damages the lungs.

Aged subjects are particularly prone to zinc and vitamin D deficiency. These two micronutrients are able to modulate the immune response by reducing the inflammatory storm.

The hypothesis is that supplementation with zinc and vitamin D would reduce the inflammatory reaction which worsens ARDS and leads to the death of subjects infected with Covid-19.

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Institutionalized

Exclusion criteria

• Life expectancy < 1 month independently of Covid-19 infection (overall subjects)
• Known hypercalcemia
• History of renal lithiasis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

Group supplementation

Experimental group

Treatment:

Dietary Supplement: Zinc gluconate

Dietary Supplement: 25-OH cholecalciferol

Group usual treatment

No Intervention group