Impact on Ovarian Reserve According to the Type of Ovarian Endometrioma Excision: Laser Versus Conventional Cystectomy

Hospital Clinic of Barcelona

Status: Completed

Conditions: Endometriosis Ovary

Treatments: Procedure: CO2 (carbon dioxide) laser vaporisation; Procedure: Stripping technique

Study type: Interventional

Funder types: Other

Identifiers

NCT03826355

OR

Details and patient eligibility

About

Endometriosis is a disease characterized by the presence of endometrial tissue outside the uterus cavity, causing important chronic pain and sterility in those patients suffering from it. It affects from 10 to 20% of women at reproductive age. Different types of endometriosis, which can coexist in the same patient, exist: deep infiltrating endometriosis (implants infiltrate > 5 mm the peritoneum), superficial endometriosis and ovarian endometriosis (OMA). OMA sometimes require surgery, and it is known that healthy ovarian tissue is also injured during resection. Consequently, ovarian reserve decreases, worsening the reproductive prognosis of patients affected. The main objective of the present study is to compare laser versus conventional OMA excision according to ovarian reserve in a pairwise-data study.

Enrollment: 16 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 18 and 45.
• Bilateral endometriomas.
• Endometrioma size > 3 cm.
• Pain and/or infertility as indication to surgical treatment.

Exclusion criteria

• History of cancer.
• Suspected malignancy.
• Evidence of premature ovarian failure.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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16 participants in 2 patient groups

Stripping technique

Active Comparator group

Description:

The endometrioma is removed according to standard surgery.

Treatment:

Procedure: Stripping technique

Laser technique

Experimental group

Description:

The endometrioma is drained, everted and then the inner wall of the endometrioma is vaporised with CO2 laser

Treatment:

Procedure: CO2 (carbon dioxide) laser vaporisation